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Efficacy Benefits of DHE and Precision Olfactory Delivery (POD) technology 1,2 In 4 randomized, double-blind, placebo-controlled studies (N=605) of a traditional dihydroergotamine mesylate (DHE) nasal spray product, 30% to 61% of patients had mild or no pain at 2 hours 1 Trudhesa with advanced POD technology consistently delivered DHE without the initial peak concentration of intravenous (IV) DHE 2 Trudhesa demonstrated rapid, sustained, consistent relief, even when taken late into an attack 2,3 * *Based on a phase 3, open-label, safety study evaluating exploratory efficacy outcomes and post hoc analyses

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